Mitochondrial Superoxide Dismutase 2 (SOD2) is a member of the iron/manganese mitochondrial superoxide dismutase family. This protein transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain, into hydrogen peroxide and oxygen. This function allows SOD2 to clear mitochondrial reactive oxygen species (ROS) and, as a result, confer protection against mitochondrial damage and cell death.
High dose vitamin C, which is a powerful antioxidant, can be effective in activating SOD2. Animal studies have shown that High-dose vitamin C inhibited oxidative stress in brain tissue. (Source 1)