Introduction: The Master Regulator of Antioxidant Defense
The NFE2L2 gene is a critical gene involved in the body’s response to oxidative stress. It encodes the transcription factor, Nrf2, which functions as the master regulator, like a ‘light switch’, for “the antioxidant response”. When activated, Nrf2 stimulates the production of many other antioxidant enzymes such as glutathione transferases (GSTs), glutathione peroxides (GPXs), superoxide dismutases (SODs), and more.
Why NFE2L2 Matters in Clinical Practice
Oxidative stress is a natural outcome of energy metabolism. Over time, accumulated oxidative stress promotes cellular damage, accelerated aging, and many different chronic diseases, including but not limited to cardiovascular, neurodegenerative, and respiratory diseases. Since oxidative stress cannot be avoided, as a natural byproduct of energy metabolism, the ability to manage it through NFE2L2 activity is relevant to all. Identifying variations in this gene provides valuable insights into antioxidant defense capacity, enabling personalized strategies to defend patients’ bodies against oxidative damage.
Early Risk Identification
Fagron’s genetic testing can help pinpoint individuals who may have reduced levels of Nrf2, leading to reduced antioxidant capacity. For these individuals, targeted nutritional strategies and lifestyle interventions can work to reduce their oxidative burden and support their cellular resources to manage oxidative stress.
Actionable Nutraceutical Recommendations
NFE2L2 expression can be induced by many dietary antioxidants, including curcumin, sulforaphane, resveratrol, quercetin, and EGCG. Multiple Nrf2-enhancing nutraceuticals can be found in Designs for Health, Detox Antiox™ product. Additionally, BroccoProtect™ is a whole food source of sulforaphane formulated by Designs for Health.
Personalized Antioxidant Support
Assessing genetic variation in NFE2L2 enables the tailoring of antioxidant support through nutrition, supplementation, and lifestyle recommendations.
How to Test NFE2L2
The NFE2L2 gene is included in several Fagron Genomics US testing panels:
- 201 Foundation / Methylation / Wellness
- 202 Immune / Autoimmune
- 204 Chronic Pain
- 206 Pro7 Comprehensive
- 210 Detoxification
- 213 Pre-Surgical
- 217 Early Childhood
- 218 Mitochondrial Health
It is also available as a Single SNP Add-On. Further insight into oxidative stress management can be found through the NAD Profile, specifically section 5, which measures metabolites linked to cellular energy and repair.
Integration Into Your Practice
Testing is convenient for both providers and patients. Kits can be shipped directly to the practice or to the patient’s home. A DNA sample is collected with a simple cheek swab, processed in Fagron Genomics US’s CLIA-certified laboratory in Austin, Texas, and results are delivered securely within 5 to 7 business days. Providers can then review the findings with their patients and recommend tailored strategies for antioxidant support.
