Healthy Methylation Pathways Are Key

The methylation cycle is the ideal pathway to focus on for nutrigenomic analysis because the proper function of this pathway is essential for over 250 processes in the body. Methylenetetrahydrofolate reductase, or MTHFR, is a key regulatory enzyme in the metabolism of folate. It also refers to a specific gene that plays a major role in the body’s methylation process. Both the enzyme and the gene have the same name, MTHFR. The gene’s role is very complex, and recent discoveries have been focused around the MTHFR gene polymorphisms (or variants). These polymorphisms are often referred to as ‘mutations’ or ‘defects’ because of the problems they cause in the body.

Most often when you hear someone talk about MTHFR, they are actually referring to one of the two common MTHFR gene mutations that causes this MTHFR enzyme to become imperfect and therefore much less effective. Simply stated, MTHFR most often refers to a genetic mutation that inhibits the body’s ability to methylate or convert folic acid from the food we eat into Methylfolate. Methylfolate is most often referred to as the ‘active’ or usable form of folate that our cells require. Because the body’s cells cannot actually use folic acid, it must first go through a metabolic pathway or 4-step conversion process to become Methylfolate before the cells can use it. It is this metabolic pathway that the MTHFR gene defect inhibits and cause methylation deficiencies and/or neuro-immune syndromes.

The learnings about this gene defect have come out and taught us that there are as many as 50+ variants of the MTHFR gene. However, only two are considered ‘common’ defects that today’s MTHFR Blood Test checks for and are the: 677 and 1298 (discovered in 1995 and 2001).

For our Foundation/Methylation/Wellness Nutrigenomic Panel, 21 genes have been chosen by our experts to be analyzed for SNPs (single nucleotide polymorphisms). The report algorithms and customized software will take the patient’s genetic results and create nutritional and lifestyle recommendations along with recommended lab work and health precautions based upon SNP results and their clinical expertise. The built-in proprietary software takes out the guess work and allows the provider to recommend the proper nutrition and health advisements safely by your DNA results.

This panel will provide insight into the following:
  • Folate and B12 Metabolism (including MTHFR gene mutation, FOLR1 gene mutation, VDR Taq gene mutation, SLC19A1 gene mutation, MTRR…)
  • Mitochondrial Polymorphism
  • Vitamin D transport
Who needs this gene panel?
  • Everyone Seeking Better Health and Nutritional Guidance
  • Anyone with Dopamine Deficiency Symptoms
  • Anyone with Serotonin Deficiency Symptoms
  • Mood Disorders
  • Chronic Fatigue
  • Neurological Symptoms
  • Immune Disorders
  • Detoxification Weakness
Why should we care about Methylation?
  • Methylation involves the addition of a “methyl” chemical group to a substrate
  • Used in over 250 biochemical processes in the body
  • Methylation is utilized in major functions of: Neurotransmitter production, Cell turnover and repair, Membrane function, Energy (mitochondrial) function, and Immune Function

“The term methylation describes a biochemical process that is utilized in the body for transport of nutrients, energy production and in gene modulation. In patients with decreased methylation activity (i.e. methylation deficiency), there are significant shortcomings in the ability to execute a variety of important chemical functions in the body. These shortcomings can leave the body unprotected from the everyday assault of environmental and infectious agents, sluggish in neurotransmitter production and slow to recover from inflammatory damage.

This shortfall can result in a wide range of medical conditions including neurological issues, such as seizures, migraines, dizziness, depression, anxiety, OCD, ADD/ADHD, developmental delay, autism, dementias and memory issues, chronic persistent infections, auto-immune disease, neural tube defects, infertility and pregnancy complications. Appropriate supplementation with the proper methylated vitamins and nutrients will bypass the genetic and acquired deficits and restore appropriate function of the pathway resulting in improvement in these complicated syndromes. The proper functioning of the methylation cycle is essential for CRITICAL reactions in the body.” – Dr. Kendal Stewart, M.D.

Learn More by investing in the Training Course

Genetic testing for methylation can help doctors and their patients better understand where in the methylation cycle an issue may be occurring because of genetic variants. Learn more about the overall benefits of genomic testing, what is analyzed, and how to better interpret the results by signing up for our exclusive Foundations in NutriGenomics Online Training Course. Gain a deeper understanding of how GX Sciences supports your development of personalized treatment options. You also gain exclusive access to GX Sciences’ Corporate Educator for scheduling dedicated calls to answer any questions you may have.

Registered? Order test kits, view sample reports, access resources, and more via our portal

Not registered yet? Submit our online registration form with your credentials and gain provider access

Want to learn more to see if GX Sciences testing is right for your practice? Schedule a consultation today