ATG16L1 rs10210302 and rs2241880
The protein encoded by the ATG16L1 is part of a large protein complex necessary for autophagy, the primary process by which intracellular components are targeted to lysosomes for degradation.
Autophagy is degrading and cleaning the inert debris in the cell. Autophagy is part of the inflammatory response and helps the immune system destroy harmful bacteria and viruses, remove debris, and self-regulate to optimal smooth function.
This mutation is related to an increased risk of several conditions, such as inappropriate immune response, chronic inflammation of intestinal walls, neurological and immunological diseases, inflammatory bowel disease (IBD), type 2 diabetes, and fatty liver disease.
A genetic risk factor explicitly associated with Crohn’s Disease (IBD) is a variant in ATG16L1 that reduces autophagy. The Crohn’s disease risk allele ATG16L1 results in abnormal Paneth cells due to decreased selective autophagy, cytokine release, and intracellular bacterial clearance.
Chron’s Disease is a type of inflammatory bowel disease that causes swelling/inflammation of the digestive tract, which leads to abdominal pain, diarrhea, fatigue, weight loss, and malnutrition. A condition that affects the quality of life and well-being of the individual.
This gene has been chosen by our experts to be analyzed in several panels of our product portfolio:
Pro 7; TBI | Post Concussion Panel; Developmental Panel; Men’s Health; Women’s Health; Gastrointestinal (GI); Autophagy; Diet & Wellness; Immune | Auto-Immune | Inflammatory; Neuro | Psych | Mood Panel.